IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3

Stable Identifier
R-HSA-8987097
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
STAT3 binds IL24:p-IL20RA:p-JAK1:IL20RB activated receptor complex, STAT3 binds p-IL20RA from IL24:IL24 receptor complex
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Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 (STAT3) are believed to bind the Interleukin-24 (IL24) receptor complex (Wang et al. 2002, Andoh et al. 2009, Parrish-Novak et al. 1998, Li et al. 2013). This is a black box event because STAT3 binding is inferred from other interleukin receptor ligand interactions where STAT3 activation is followed by a transient interaction with the receptor complex e.g.Interleukin-10 receptor (Weber-Nordt et al. 1996).

Literature References
PubMed ID Title Journal Year
18941194 IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression

Sainz-Perez, A, Gary-Gouy, H, Gaudin, F, Maarof, G, Marfaing-Koka, A, de Revel, T, Dalloul, A

J. Immunol. 2008
19535621 Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease

Andoh, A, Shioya, M, Nishida, A, Bamba, S, Tsujikawa, T, Kim-Mitsuyama, S, Fujiyama, Y

J. Immunol. 2009
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