IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11

Stable Identifier
R-HSA-8987132
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
PTPN11 binds to IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 activated receptor complex, PTPN11 binds to IL22 receptor complex, Shp2 is recruited to the tyrosine phosphorylated IL-22R1
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Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP2) binds the Interleukin-22 (IL22) receptor complex. Tyrosines 251 and 301 of IL22RA1 are required for PTPN11 binding (Meng et al. 2010).

Literature References
PubMed ID Title Journal Year
20671117 Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation

Meng, S, Gui, Q, Xu, Q, Lu, K, Jiao, X, Fan, J, Ge, B, Ke, Y, Zhang, S, Wu, J, Wang, C

J Mol Cell Biol 2010
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