Reactome | p-Y-STAT2 [cytosol]

p-Y-STAT2 [cytosol]

Stable Identifier

R-HSA-8987235

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
17006906	Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes Doyle, SE, Schreckhise, H, Khuu-Duong, K, Henderson, K, Rosler, R, Storey, H, Yao, L, Liu, H, Barahmand-pour, F, Sivakumar, P, Chan, C, Birks, C, Foster, D, Clegg, CH, Wietzke-Braun, P, Mihm, S, Klucher, KM	Hepatology	2006

External Reference Information

External Reference

UniProt:P52630 STAT2

Gene Names

STAT2

Chain

chain:1-851

Reference Genes

BioGPS Gene:6773 STAT2

COSMIC (genes):STAT2 STAT2

CTD Gene:6773 STAT2

dbSNP Gene:6773 STAT2

ENSEMBL:ENSG00000170581 STAT2

HGNC:11363 STAT2

KEGG Gene (Homo sapiens):6773 STAT2

Monarch:6773 STAT2

NCBI Gene:6773 STAT2

OMIM:600556 STAT2

UCSC:P52630 STAT2

Reference Transcript

Other Identifiers

0001990411

11718652_a_at

11752794_a_at

11752795_x_at

11755147_s_at

1244_at

16766093

205170_at

217199_3p_s_at

217199_s_at

225636_at

3457753

3457754

3457755

3457756

3457757

3457758

3457759

3457760

3457763

3457765

3457766

3457767

3457770

3457772

3457775

3457777

3457778

3457779

3457781

3457782

3457784

3457785

3457786

3457787

3457788

3457789

3457790

36770_at

52062_f_at

6773

7964119

91777_s_at

A_23_P76090

A_33_P3213064

GE58983

GO:0000228

GO:0000790

GO:0000978

GO:0000981

GO:0001228

GO:0001932

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006464

GO:0006950

GO:0006952

GO:0007005

GO:0007165

GO:0007259

GO:0008150

GO:0008283

GO:0009058

GO:0016032

GO:0019221

GO:0019899

GO:0034641

GO:0042127

GO:0042802

GO:0043226

GO:0043434

GO:0044389

GO:0044403

GO:0045944

GO:0048856

GO:0051607

GO:0060337

GO:0090140

Hs.247981.0.S1_3p_s_at

Hs.42491.0.S1_3p_at

ILMN_1690921

PH_hs_0028948

TC12001602.hg

U18671_rna1_at

g4885614_3p_at

Participant Of

hasMember

p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4,p-STAT5 [cytosol]

Other forms of this molecule

STAT2 [cytosol]

p-Y690-STAT2 [cytosol]

p-Y690-STAT2 [nucleoplasm]

Inferred To

phospho-Stat2 [cytosol] (Mus musculus)

phospho-Stat2 [cytosol] (Rattus norvegicus)

phospho-STAT2 [cytosol] (Bos taurus)

phospho-STAT2 [cytosol] (Canis familiaris)

phospho-p-Y-STAT2 [cytosol] (Gallus gallus)

phospho-stat2 [cytosol] (Danio rerio)

phospho-stat2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005410.1, NP_938146.1

OpenTargets

ENSG00000170581

GeneCards

P52630

HPA

ENSG00000170581-STAT2

Ensembl

ENSP00000315768, ENSG00000170581, ENST00000557235, ENST00000314128, ENSP00000450751

PRO

P52630

Orphanet

23276

PDB

2KA4

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42224 STAT1	7	p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905)	0.859	15
UniProt:Q00978 IRF9	2	IRF9 [cytosol] (R-HSA-879183) IRF9 [nucleoplasm] (R-HSA-913522)	0.793	7
UniProt:P17181 IFNAR1	2	p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675) IFNAR1 [plasma membrane] (R-HSA-877334)	0.758	5
UniProt:P48551 IFNAR2			0.688	4
UniProt:P0C774 V			0.576	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:P52630 STAT2	4	STAT2 [cytosol] (R-HSA-882029) p-Y-STAT2 [cytosol] (R-HSA-8987235) p-Y690-STAT2 [cytosol] (R-HSA-909683) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673)	0.532	3
UniProt:Q77PU6 U90			0.524	2
UniProt:P11207 V			0.508	2
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.488	2

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