Reactome | p-Y-STAT2 [cytosol]

p-Y-STAT2 [cytosol]

Stable Identifier

R-HSA-8987235

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Icon

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
17006906	Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes Doyle, SE, Schreckhise, H, Khuu-Duong, K, Henderson, K, Rosler, R, Storey, H, Yao, L, Liu, H, Barahmand-pour, F, Sivakumar, P, Chan, C, Birks, C, Foster, D, Clegg, CH, Wietzke-Braun, P, Mihm, S, Klucher, KM	Hepatology	2006

External Reference Information

External Reference

UniProt:P52630 STAT2

Gene Names

STAT2

Chain

chain:1-851

Reference Genes

BioGPS Gene:6773 STAT2

COSMIC (genes):STAT2 STAT2

CTD Gene:6773 STAT2

dbSNP Gene:6773 STAT2

ENSEMBL:ENSG00000170581 STAT2

HGNC:11363 STAT2

KEGG Gene (Homo sapiens):6773 STAT2

Monarch:6773 STAT2

NCBI Gene:6773 STAT2

OMIM:600556 STAT2

UCSC:P52630 STAT2

Reference Transcript

Other Identifiers

0001990411

11718652_a_at

11752794_a_at

11752795_x_at

11755147_s_at

1244_at

16766093

18888

205170_at

217199_3p_s_at

217199_s_at

225636_at

2KA4

3457753

3457754

3457755

3457756

3457757

3457758

3457759

3457760

3457763

3457765

3457766

3457767

3457770

3457772

3457775

3457777

3457778

3457779

3457781

3457782

3457784

3457785

3457786

3457787

3457788

3457789

3457790

36770_at

3858

52062_f_at

6773

7964119

91777_s_at

A_23_P76090

A_33_P3213064

AAA98760

AAB36226

AAB36227

AAH51284

AAS00091

AC025574

AFM91192

AFM91193

AFM91194

AFM91197

AFM91198

AFM91199

AFM91200

AFM91202

AFM91203

AFM91204

AFM91205

AFM91206

AFM91207

AFM91208

AFM91209

AFM91212

AFM91213

AFM91214

AFM91216

AFM91221

AFM91223

AFM91225

AFM91226

AFM91227

AFM91228

AFM91229

AFM91230

AFM91231

AFM91232

AFM91234

AFM91235

AFM91236

AFM91238

AFM91239

AFM91240

AFM91241

AFM91243

AFM91244

AFM91245

AFM91246

AFM91247

AFM91249

AFM91251

AFM91252

AFM91253

AFM91255

AFM91258

AFM91262

AK296939

AY525126

B4DLC8

BAG59489

BC051284

CAB003858

CCDS55836

CCDS8917

CH471054

EAW96934

EAW96935

EAW96937

ENSG00000170581

ENSP00000315768

ENSP00000450751

ENST00000314128

ENST00000557235

ENST00000557235.5

EntrezGene:6773

EntrezGene:STAT2

G3V319

g4885614_3p_at

GE58983

GO:0000978

GO:0000981

GO:0001228

GO:0001932

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006464

GO:0006950

GO:0006952

GO:0007005

GO:0007165

GO:0007259

GO:0008150

GO:0008283

GO:0009058

GO:0016032

GO:0019221

GO:0019899

GO:0034641

GO:0042127

GO:0042802

GO:0043226

GO:0043434

GO:0044389

GO:0044403

GO:0045944

GO:0048856

GO:0051607

GO:0060337

GO:0090140

HGNC:11363

HPA018888

Hs.247981.0.S1_3p_s_at

Hs.42491.0.S1_3p_at

ILMN_1690921

IPR000980

IPR001217

IPR008967

IPR012345

IPR013799

IPR013800

IPR013801

IPR015988

IPR022756

IPR035854

IPR036535

IPR036860

JX178204

JX178205

JX178206

JX178208

JX178209

JX178210

JX178211

JX178213

JX178214

JX178215

JX178216

JX178217

JX178218

JX178219

JX178220

JX178223

JX178224

JX178225

JX178227

JX178232

JX178234

JX178236

JX178237

JX178238

JX178239

JX178240

JX178241

JX178242

JX178243

JX178245

JX178246

JX178247

JX178249

JX178250

JX178251

JX178252

JX178254

JX178255

JX178256

JX178257

JX178258

JX178260

JX178262

JX178263

JX178264

JX178266

JX178269

JX178273

LRG_1329

M97934

MIM:600556

MIM:616636

NM_005419

NM_198332

NP_005410

NP_938146

PF00017

PF01017

PF02864

PF02865

PF12188

PH_hs_0028948

R9QE65

S81491

SM00252

SM00964

STAT2

STAT2-201

STAT2-210

TC12001602.hg

U18671

U18671_rna1_at

UPI00000473FC

UPI0001CB7F8B

XM_011538697

XM_011538698

XM_011538699

XM_011538700

XM_017019904

XP_011536999

XP_011537000

XP_011537001

XP_011537002

XP_016875393

XR_002957375

XR_002957376

Participant Of

hasMember

p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4,p-STAT5 [cytosol]

Other forms of this molecule

STAT2 [cytosol]

p-Y690-STAT2 [cytosol]

p-Y690-STAT2 [nucleoplasm]

Inferred To

phospho-p-Y-STAT2 [cytosol] (Bos taurus)

phospho-p-Y-STAT2 [cytosol] (Canis familiaris)

phospho-p-Y-STAT2 [cytosol] (Danio rerio)

phospho-p-Y-STAT2 [cytosol] (Gallus gallus)

phospho-p-Y-STAT2 [cytosol] (Mus musculus)

phospho-p-Y-STAT2 [cytosol] (Rattus norvegicus)

phospho-p-Y-STAT2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005410.1, NP_938146.1

OpenTargets

ENSG00000170581

GeneCards

P52630

PRO

P52630

Orphanet

23276

PDB

2KA4

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42224 STAT1	7	p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.859	15
UniProt:Q00978 IRF9	2	IRF9 [cytosol] (R-HSA-879183) IRF9 [nucleoplasm] (R-HSA-913522)	0.793	7
UniProt:P17181 IFNAR1	2	p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675) IFNAR1 [plasma membrane] (R-HSA-877334)	0.758	5
UniProt:P48551 IFNAR2			0.688	4
UniProt:P0C774 V			0.576	4
UniProt:P52630 STAT2	4	STAT2 [cytosol] (R-HSA-882029) p-Y-STAT2 [cytosol] (R-HSA-8987235) p-Y690-STAT2 [cytosol] (R-HSA-909683) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673)	0.532	3
UniProt:Q77PU6 U90			0.524	2
UniProt:P11207 V			0.508	2
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.488	2