Phospho-JAK2 phosphorylates EPOR

Stable Identifier
R-HSA-9006323
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Phospho-JAK2 phosphorylates EPOR
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Phosphorylated JAK2 phosphorylates 8 tyrosine residues in the cytoplasmic tail of EPOR (Dusanter-Fourt et al. 1992, McGraw et al. 2012, and inferred from mouse homologs). The phosphorylated residues then serve as binding sites for scaffold proteins such as CRKL and GAB1 and downstream signaling proteins such as STAT5, phospholipase C, and phosphatidylinositol 3-kinase.
Literature References
PubMed ID Title Journal Year
1375226 Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells

Mayeux, P, Lacombe, C, Billat, C, Fischer, S, Casadevall, N, Dusanter-Fourt, I, Muller, O

J. Biol. Chem. 1992
22509308 Erythropoietin receptor signaling is membrane raft dependent

Clark, JA, Johnson, JO, McGraw, KL, Sokol, L, Fuhler, GM, Caceres, GC, List, AF

PLoS ONE 2012
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of EPO:EPOR:p-Y12-JAK2:LYN:IRS2 [plasma membrane]

Physical Entity
EPO:EPOR:p-Y12-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phospho-Jak2 phosphorylates Epor (Mus musculus)
Authored
May, B  (2017-04-22)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-05-13)
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