Reactome | EPO binds EPOR:JAK2:LYN:IRS2

EPO binds EPOR:JAK2:LYN:IRS2

Stable Identifier

R-HSA-9006325

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Extracellular Erythropoietin (EPO) binds the EPO receptor (EPOR) located in the plasma membrane of the target cell (Jones et al. 1990, Syed et al. 1998, Remy et al. 1999, and inferred from mouse homologs). EPOR is a dimer that appears to be preassociated with downstream signaling proteins JAK2 (inferred from mouse homologs) and LYN (Chin et al. 1998, and inferred from mouse homologs) and the scaffold protein IRS2 (Verdier et al. 1997). Binding of EPO to EPOR causes a change in the conformation of the dimer which activates JAK2 (Syed et al. 1998, Remy et al. 1999, Kubatzky et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
9334184	Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation Mayeux, P, Lacombe, C, Billat, C, Verdier, F, Gisselbrecht, S, Chrétien, S	J. Biol. Chem.	1997
9974393	Erythropoietin receptor activation by a ligand-induced conformation change Wilson, IA, Michnick, SW, Remy, I	Science	1999
2163696	Human erythropoietin receptor: cloning, expression, and biologic characterization D'Andrea, AD, Haines, LL, Wong, GG, Jones, SS	Blood	1990
9573010	Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway Wakao, H, Chin, H, Kamiyama, R, Arai, A, Miura, O, Miyasaka, N	Blood	1998
9774108	Efficiency of signalling through cytokine receptors depends critically on receptor orientation Finer-Moore, J, Wendoloski, JJ, Egrie, J, Li, C, Chirino, AJ, Zhang, J, Katz, BA, Matthews, DJ, Syed, RS, Stroud, RM, Aoki, KH, Osslund, TD, Sitney, K, Elliott, S, Reid, SW, Zhan, H, Liu, B, Cheetham, JC	Nature	1998
11231127	Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor Langosch, D, Ruan, W, Watowich, SS, Cohen, J, Ketteler, R, Klingmüller, U, Gurezka, R, Neumann, D, Kubatzky, KF	Curr. Biol.	2001