IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3

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R-HSA-9006422
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Reaction [omitted]
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Homo sapiens
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Binding of the RUNX1:CBFB complex to the interferon gamma (IFNG) gene promoter stimulates IFNG transcription. If FOXP3 is present in the complex with RUNX1, the IFNG gene transcription is inhibited. Suppressed IFNG production is one of the hallmarks of regulatory T cells (Tregs) (Ono et al. 2007).

Literature References
PubMed ID Title Journal Year
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M, Yaguchi, H, Ohkura, N, Kitabayashi, I, Nagamura, Y, Nomura, T, Miyachi, Y, Tsukada, T, Sakaguchi, S

Nature 2007
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