PTPN4 gene expression is stimulated by MECP2

Stable Identifier
R-HSA-9006585
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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PTPN4 gene expression is stimulated by MECP2
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Binding of MECP2 to the PTPN4 gene promoter stimulates PTPN4 transcription. PTPN4 gene encodes a protein tyrosine phosphatase, non-receptor type, also known as MEG, PTPase-MEG1 or PTPMEG. Expression of Ptpn4 is reduced in Mecp2 null mice used as a Rett syndrome model. A hemizygous PTPN4 gene deletion was found in twins with a Rett-like phenotype (Williamson et al. 2015).
Literature References
PubMed ID Title Journal Year
25424712 Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype

Pelka, GJ, Ellaway, CJ, Williamson, SL, Tam, PPL, Peters, GB, Christodoulou, J

Eur. J. Hum. Genet. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MECP2:PTPN4 gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-17)
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