Reactome | IL21 receptor JAK phosphorylation

IL21 receptor JAK phosphorylation

Stable Identifier

R-HSA-9006850

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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The IL21 heteromeric receptor complex can activate JAK1 and JAK3 in response to Interleukin-21 (IL21), leading to JAK tyrosine phosphorylation (Asao et al. 2001, Habib et al. 2002).

This is a black box event because the mechanism leading to JAK phosphorylation is not established for this receptor complex.

Literature References

PubMed ID	Title	Journal	Year
12093291	The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3 Weinberg, K, Senadheera, S, Kaushansky, K, Habib, T	Biochemistry	2002
11418623	Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex Ishii, N, Okuyama, C, Foster, D, Asao, H, Kumaki, S, Sugamura, K, Tsuchiya, S	J. Immunol.	2001