Reactome | IL21 receptor JAK phosphorylation

IL21 receptor JAK phosphorylation

Stable Identifier

R-HSA-9006850

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

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The IL21 heteromeric receptor complex can activate JAK1 and JAK3 in response to Interleukin-21 (IL21), leading to JAK tyrosine phosphorylation (Asao et al. 2001, Habib et al. 2002).

This is a black box event because the mechanism leading to JAK phosphorylation is not established for this receptor complex.

Literature References

PubMed ID	Title	Journal	Year
11418623	Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex Asao, H, Okuyama, C, Kumaki, S, Ishii, N, Tsuchiya, S, Foster, D, Sugamura, K	J. Immunol.	2001
12093291	The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3 Habib, T, Senadheera, S, Weinberg, K, Kaushansky, K	Biochemistry	2002