The IL21 heteromeric receptor complex can activate JAK1 and JAK3 in response to Interleukin-21 (IL21), leading to JAK tyrosine phosphorylation (Asao et al. 2001, Habib et al. 2002).This is a black box event because the mechanism leading to JAK phosphorylation is not established for this receptor complex.
Asao, H, Okuyama, C, Kumaki, S, Ishii, N, Tsuchiya, S, Foster, D, Sugamura, K
Habib, T, Senadheera, S, Weinberg, K, Kaushansky, K
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