IL21 receptor JAK phosphorylation

Stable Identifier
R-HSA-9006850
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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IL21 receptor JAK phosphorylation
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The IL21 heteromeric receptor complex can activate JAK1 and JAK3 in response to Interleukin-21 (IL21), leading to JAK tyrosine phosphorylation (Asao et al. 2001, Habib et al. 2002).

This is a black box event because the mechanism leading to JAK phosphorylation is not established for this receptor complex.

Literature References
PubMed ID Title Journal Year
11418623 Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

Asao, H, Okuyama, C, Kumaki, S, Ishii, N, Tsuchiya, S, Foster, D, Sugamura, K

J. Immunol. 2001
12093291 The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

Habib, T, Senadheera, S, Weinberg, K, Kaushansky, K

Biochemistry 2002
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Orthologous Events
IL21 receptor JAK phosphorylation (Canis familiaris)
IL21 receptor JAK phosphorylation (Danio rerio)
IL21 receptor JAK phosphorylation (Gallus gallus)
IL21 receptor JAK phosphorylation (Mus musculus)
IL21 receptor JAK phosphorylation (Rattus norvegicus)
IL21 receptor JAK phosphorylation (Sus scrofa)
Authored
Jupe, S  (2017-05-11)
Reviewed
Meldal, BH  (2017-11-03)
Created
Jupe, S  (2017-05-23)
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