Integrin signaling

Stable Identifier
R-HSA-9006921
Type
Pathway
Species
Homo sapiens
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Integrins are a major family of cell surface receptors that modulate cell adhesion, migration, proliferation and survival through interaction with the extracellular matrix (ECM) and the actin cytoskeleton. Integrins are type 1 transmembrane proteins that exist at the cell surface as heterodimers of alpha and beta subunits, of which there are 18 and 8 different isoforms, respectively, in human cells. In addition to their mechanical role in mediating contact between the ECM and the cytoskeleton, integrins also modulate intracellular signaling pathways governing cytoskeletal rearrangements and pro-survival and mitogenic signaling (reviewed in Hehlgans et al, 2007; Harburger and Calderwood, 2009; Ata and Antonescu, 2017).

Literature References
PubMed ID Title Journal Year
19118207 Integrin signalling at a glance

Harburger, DS, Calderwood, DA

J. Cell. Sci. 2009
28106780 Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer

Ata, R, Antonescu, CN

Int J Mol Sci 2017
17084981 Signalling via integrins: implications for cell survival and anticancer strategies

Hehlgans, S, Haase, M, Cordes, N

Biochim Biophys Acta 2007
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