Intracellular signaling by second messengers

Stable Identifier
R-HSA-9006925
Type
Pathway
Species
Homo sapiens
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Second messengers are generated within the cell as a downstream step in signal transduction cascades initiated by the interaction of an external stimulus with a cell surface receptor. Common second messengers include DAG, cAMP, cGMP, IP3, Ca2+ and phosphatidylinositols (reviewed in Kang et al, 2015; Raker et al, 2016; Li and Marshall, 2015; Pinto et al, 2015; Ahmad et al, 2015).

Literature References
PubMed ID Title Journal Year
26275497 Calcium signaling and cell proliferation

Pinto, MC, Kihara, AH, Goulart, VA, Tonelli, FM, Gomes, KN, Ulrich, H, Resende, RR

Cell. Signal. 2015
26588873 Roles of phosphoinositide-specific phospholipase Cγ1 in brain development

Kang, DS, Yang, YR, Lee, C, Kim, S, Ryu, SH, Suh, PG

Adv Biol Regul 2016
27065076 The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases

Raker, VK, Becker, C, Steinbrink, K

Front Immunol 2016
26922871 Signalling at membrane contact sites: two membranes come together to handle second messengers

Levine, TP, Patel, S

Curr. Opin. Cell Biol. 2016
25056711 Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets

Ahmad, F, Murata, T, Shimizu, K, Degerman, E, Maurice, D, Manganiello, V

Oral Dis 2015
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