Reactome: A Curated Pathway Database

Signaling by Non-Receptor Tyrosine Kinases

Stable Identifier
R-HSA-9006927
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

In addition to receptor tyrosine kinases, the human genome encodes at least 32 non-receptor tyrosine kinases (non-RTKs). These cytosolic tyrosine kinases lack a transmembrane domain but are recruited into signal transduction cascades through interaction with other plasma-bound receptors, which may or may not themselves have intrinsic catalytic activity. In this way, non-RTKs essentially function as an (additional) enzymatic subunit of the signaling complex and contribute to many of the same downstream signaling pathways. The non-RTKs can be grouped into 9 families (ABL, FES, SYK, JAK, TEC, FAK, ACK, SRC, FRK and CSK) based on their domain structure (reviewed in Neet and Hunter, 1996).

Literature References
PubMed ID Title Journal Year
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Orthologous Events