Reactome: A Curated Pathway Database

Signaling by TGF-beta family members

Stable Identifier
R-HSA-9006936
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The human genome encodes 33 TGF-beta family members, including TGF-beta itself, as well as bone morphogenetic protein (BMP), activin, nodal and growth and differentiation factors (GDFs). This superfamily of ligands generally binds as dimers to hetero-tetrameric cell-surface receptor serine/threonine kinases to activate SMAD-dependent and SMAD-independent signaling (reviewed in Morikawa et al, 2016; Budi et al, 2017).

Literature References
Participants
Participant Of
Orthologous Events