CDC7 gene expression is repressed by the PRC1L4 complex

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R-HSA-9007462
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Reaction [omitted]
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Homo sapiens
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Binding of the PRC1L4 complex, composed of E2F6, CBX3 (HP1gamma), PCGF6 (MBLR), L3MBTL2 and RING1 or RNF2, to the CDC7 gene promoter represses CDC7 transcription. This is concluded based on experimental evidence of direct association of the PRC1L4 complex with the CDC7 gene promoter and increased CDC7 expression upon E2F6 or L3MBTL2 knockdown (Trojer et al. 2011).

Literature References
PubMed ID Title Journal Year
21596310 L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

Trojer, P, Cao, AR, Gao, Z, Li, Y, Zhang, J, Xu, X, Li, G, Losson, R, Erdjument-Bromage, H, Tempst, P, Farnham, PJ, Reinberg, D

Mol. Cell 2011
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