The PRC1L4 complex binds the UXT gene promoter

Stable Identifier
R-HSA-9007464
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The PRC1L4 complex, consisting of E2F6, CBX3 (HP1gamma), PCGF6 (MBLR), L3MBTL2, and RING1 (RING1A) or RNF2 (RING2, also known as RING1B), binds the promoter of the UXT gene (Trojer et al. 2011). E2F6 was also reported to bind to the UXT promoter by Oberley et al. 2003.

Literature References
PubMed ID Title Journal Year
21596310 L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

Trojer, P, Cao, AR, Gao, Z, Li, Y, Zhang, J, Xu, X, Li, G, Losson, R, Erdjument-Bromage, H, Tempst, P, Farnham, PJ, Reinberg, D

Mol. Cell 2011
12909625 E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9

Oberley, MJ, Inman, DR, Farnham, PJ

J. Biol. Chem. 2003
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