E2F6 binds RRM2 gene promoter

Stable Identifier
R-HSA-9007591
Type
Reaction [binding]
Species
Homo sapiens
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E2F6, presumably in complex with at least TFDP1 (DP-1) or TFDP2 (DP-2), binds the promoter of the E2F1 target gene RRM2. Binding of E2F6 to the RRM2 promoter is inhibited by CHEK1 mediated phosphorylation of E2F6 (Bertoli et al. 2013).

Literature References
PubMed ID Title Journal Year
23954429 Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

Bertoli, C, Klier, S, McGowan, C, Wittenberg, C, de Bruin, RA

Curr. Biol. 2013
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