E2F6 binds RRM2 gene promoter

Stable Identifier
R-HSA-9007591
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E2F6 binds RRM2 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E2F6, presumably in complex with at least TFDP1 (DP-1) or TFDP2 (DP-2), binds the promoter of the E2F1 target gene RRM2. Binding of E2F6 to the RRM2 promoter is inhibited by CHEK1 mediated phosphorylation of E2F6 (Bertoli et al. 2013).

Literature References
PubMed ID Title Journal Year
23954429 Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

Bertoli, C, McGowan, C, Klier, S, Wittenberg, C, de Bruin, RA

Curr. Biol. 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-S317,S345-CHEK1 [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-01)
Reviewed
Herlihy, A  (2017-05-12)
Created
Orlic-Milacic, M  (2017-05-31)
Cite Us!