Reactome | RUNX2-P2 [cytosol]

RUNX2-P2 [cytosol]

Stable Identifier

R-HSA-9007987

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RUNX2-proximal

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13950-2 RUNX2

Gene Names

RUNX2, AML3, CBFA1, OSF2, PEBP2A

Participates

as an output of

RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)

as a candidate of

RUNX2 [cytosol] (Homo sapiens)

Other forms of this molecule

RUNX2-P2 [nucleoplasm]

p-S280,S298-RUNX2-P2 [nucleoplasm]

p-S451-RUNX2-P2 [nucleoplasm]

p-S418-RUNX2-P2 [nucleoplasm]

PolyUb-RUNX2-P2 [cytosol]

PolyUb-RUNX2-P2 [nucleoplasm]

p-S280,S284,S288-RUNX2-P2 [nucleoplasm]

p-S182,T184,T186-RUNX2-P2 [nucleoplasm]

Inferred To

RUNX2-P2 [cytosol] (Bos taurus)

RUNX2-P2 [cytosol] (Caenorhabditis elegans)

RUNX2-P2 [cytosol] (Danio rerio)

RUNX2-P2 [cytosol] (Gallus gallus)

RUNX2-P2 [cytosol] (Xenopus tropicalis)

Runx2 [cytosol] (Mus musculus)

RUNX2 [cytosol] (Canis familiaris)

RUNX2 [cytosol] (Sus scrofa)

RunxB [cytosol] (Drosophila melanogaster)

RunxA [cytosol] (Drosophila melanogaster)

Homologues of RUNX2-P2 [cytosol] (Drosophila melanogaster)

lz [cytosol] (Drosophila melanogaster)

run [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000124813

ENSEMBL

ENST00000359524, ENST00000371438, ENST00000371436, ENSP00000360493, ENSP00000360491, ENSP00000495497, ENST00000371432, ENSG00000124813, ENST00000647337, ENSP00000360486, ENSP00000352514

HPA

ENSG00000124813-RUNX2

GeneCards

RUNX2

PRO

Q13950

Pharos - Targets

Q13950

Orphanet

RUNX2

GlyGen

Q13950

PDB

6VGE, 6VG8, 6VGD, 6VGG

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.602	4
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.591	7
UniProt:P17480 UBTF	2	UBTF [nucleoplasm] (R-HSA-73683) p-UBTF [nucleoplasm] (R-HSA-76039)	0.564	4
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.527	3

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