NCOA1 binds ESR1:estrogen:TGFA gene

Stable Identifier
R-HSA-9008270
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NCOA1 is a nuclear receptor coactivator that is recruited to the TGFA promoter through direct interaction with ESR1 (Halachmi et al, 1994; Cavaillès et al, 1994; Harnstein et al, 2001). Although NCOA1 has intrinsic histone acetyltransferase activity, it plays a more predominant role in activating gene transcription through its ability to recruit EP300 to the promoter (Harnstein et al, 2001; reviewed in Arnal el al, 2017).

Literature References
PubMed ID Title Journal Year
8197458 Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription

Halachmi, S, Marden, E, Martin, G, MacKay, H, Abbondanza, C, Brown, M

Science 1994
7937828 Interaction of proteins with transcriptionally active estrogen receptors

Cavaillès, V, Dauvois, S, Danielian, PS, Parker, MG

Proc. Natl. Acad. Sci. U.S.A. 1994
8876171 p300 is a component of an estrogen receptor coactivator complex

Hanstein, B, Eckner, R, DiRenzo, J, Halachmi, S, Liu, H, Searcy, B, Kurokawa, R, Brown, M

Proc. Natl. Acad. Sci. U.S.A. 1996
Participants
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