Reactome | NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3

NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3

Stable Identifier

R-HSA-9008285

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3

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Cryoelectron microscopy (cryo-EM) determined the quaternary structure of an active complex of DNA-bound ESR1, steroid receptor coactivator 3 (SRC3 or NCOA3), and a secondary coactivator (p300/EP300). A structural model suggests the following assembly mechanism for the complex: each of the two ligand-bound ESR1 monomers independently recruits one NCOA3 protein via the transactivation domain of ESR1;the two NCOA3s in turn bind to different regions of one p300 protein through multiple contacts (Yi P et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25728767	Structure of a biologically active estrogen receptor-coactivator complex on DNA O'Malley, BW, Pintilie, GD, Foulds, CE, Yi, P, Ludtke, SJ, Lanz, RB, Feng, Q, Chiu, W, Schmid, MF, Wang, Z	Mol. Cell	2015