GSK3B phosphorylates RUNX2

Stable Identifier
R-HSA-9008480
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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GSK3B phosphorylates RUNX2
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GSK3B phosphorylates RUNX2 on three serine residues in an evolutionarily conserved motif SPPWSYDQS, which decreases the DNA binding ability of RUNX2 (Kugimiya et al. 2007).
Literature References
PubMed ID Title Journal Year
17786208 GSK-3beta controls osteogenesis through regulating Runx2 activity

Woodgett, JR, Kawamura, N, Ohba, S, Kawaguchi, H, Kugimiya, F, Chung, UI, Nakamura, K, Chikuda, H, Azuma, Y, Hirata, M

PLoS ONE 2007
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of RUNX2:GSK3B [nucleoplasm]

Physical Entity
RUNX2:GSK3B [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
GSK3B phosphorylates Runx2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-10)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-10)
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