Reactome | IL37:IL18R1 binds SIGIRR

IL37:IL18R1 binds SIGIRR

Stable Identifier

R-HSA-9008577

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IL-37:IL-18R1 binds SIGIRR

ReviewStatus

5/5

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Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. IL-37 can bind the Interleukin-18 receptor 1 (IL-18R1) (Shi et al. 2003, Kumar et al. 2002). Upon binding to IL-18R1, IL-37 facilitates the recruitment of Single Ig IL 1 related receptor (SIGIRR, TIR-8, IL-1R8) forming a complex (Nold Petry et al. 2015). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation.

Literature References

PubMed ID	Title	Journal	Year
25729923	IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction Lotz-Havla, AS, Dinarello, CA, Li, S, Rossello, FJ, Garlanda, C, Gersting, SW, Nold, MF, Rudloff, I, Bufler, P, Lo, CY, Azam, T, Lao, JC, Cho, SX, Gantier, MP, Mantovani, A, Elgass, KD, Whisstock, JC, Rotter, B, Nold-Petry, CA, Ellisdon, AM, Mangan, NE	Nat. Immunol.	2015