Reactome | IL37 [cytosol]

IL37 [cytosol]

Stable Identifier

R-HSA-9008596

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IL-37, Interleukin-37 isoform b, IL-37_HUMA isoform b

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NZH6 IL37

Gene Names

IL37, FIL1Z, IL1F7, IL1H4, IL1RP1

Chain

propeptide:1-45, chain:46-218

Reference Genes

BioGPS Gene:27178 IL37

COSMIC (genes):IL37 IL37

CTD Gene:27178 IL37

dbSNP Gene:27178 IL37

ENSEMBL:ENSG00000125571 IL37

ENSEMBL_homo_sapiens_GENE:ENSG00000125571.10 IL37

HGNC:15563 IL37

KEGG Gene (Homo sapiens):27178 IL37

Monarch:27178 IL37

NCBI Gene:27178 IL37

OMIM:605510 IL37

UCSC:Q9NZH6 IL37

Reference Transcript

Other Identifiers

11732837_a_at

16884582

221470_PM_s_at

221470_s_at

224555_PM_x_at

224555_x_at

2501076

2501077

2501078

2501079

2501080

2501082

2501084

2501085

2501086

27178

8044532

84828_at

A_23_P5654

GE62323

GO:0002376

GO:0002437

GO:0005125

GO:0005149

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006954

GO:0006955

GO:0010628

GO:0019221

GO:0023052

GO:0032715

GO:0032720

GO:0043226

GO:0043231

GO:0048018

GO:0050727

GO:0071222

GO:0098772

HMNXSV003001997

ILMN_1697710

ILMN_1718275

ILMN_2353936

PH_hs_0010018

TC02000714.hg

g10185739_3p_a_at

Participates

as an input of

IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Homo sapiens)

as a component of

IL37:2x(CASP1(120-197):CASP1(317-404)) [cytosol] (Homo sapiens)

as a member of

IL37,IL37(?-218) [cytosol] (Homo sapiens)

Other forms of this molecule

IL37(?-218) [nucleoplasm]

IL37(1-?) [cytosol]

IL37(?-218) [extracellular region]

IL37 [extracellular region]

IL37(?-218) [cytosol]

Inferred To

il1fma [cytosol] (Danio rerio)

Homologues of IL37 [cytosol] (Xenopus tropicalis)

IL37 [cytosol] (Bos taurus)

il1b [cytosol] (Xenopus tropicalis)

IL36G [cytosol] (Canis familiaris)

LOC105946938 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011509266.1, NP_775296.1, NP_775295.1, NP_775294.1, XP_011509265.1, NP_775297.1, NP_055254.2

OpenTargets

ENSG00000125571

HPA

ENSG00000125571-IL37

GeneCards

Q9NZH6

Ensembl

ENST00000353225, ENST00000311328, ENSP00000263326, ENSP00000263327, ENSG00000125571, ENSP00000309883, ENST00000263326, ENST00000349806, ENSP00000263328, ENST00000352179, ENSP00000309208

PRO

Q9NZH6

Pharos - Targets

Q9NZH6

PDB

6NCU, 5HN1

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	5
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.463	2

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