IL37(?-218) binds SMAD3

Stable Identifier
R-HSA-9008692
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
IL-37(?-218) binds SMAD3
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Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. The putative caspase 1 cleavage site is at aspartic acid 20 (Kumar et al. 2002). Mothers against decapentaplegic homolog 3 (SMAD3) binds SMAD4 and this complex modulates the transcription of several genes downstream. IL-37(? 218) can bind SMAD3 (Nold M F et al. 2010, Grimsby S et al. 2004) and may affect its function.

Literature References
PubMed ID Title Journal Year
15527767 Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity

Grimsby, S, Jaensson, H, Dubrovska, A, Lomnytska, M, Hellman, U, Souchelnytskyi, S

FEBS Lett. 2004
20935647 IL-37 is a fundamental inhibitor of innate immunity

Nold, MF, Nold-Petry, CA, Zepp, JA, Palmer, BE, Bufler, P, Dinarello, CA

Nat. Immunol. 2010
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