Reactome | BAX gene expression is stimulated by RUNX2

BAX gene expression is stimulated by RUNX2

Stable Identifier

R-HSA-9008839

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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BAX gene expression is stimulated by RUNX2

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BAX gene transcription is directly stimulated by binding of RUNX2, presumably in complex with CBFB, to RUNX2 response elements in the BAX promoter (Eliseev et al. 2008, Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22065775	Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents Goloudina, AR, Tanoue, K, Hammann, A, Fourmaux, E, le Guezennec, X, Bulavin, DV, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON	Proc. Natl. Acad. Sci. U.S.A.	2012
18223689	Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis Eliseev, RA, Dong, YF, Sampson, E, Zuscik, MJ, Schwarz, EM, O'Keefe, RJ, Rosier, RN, Drissi, MH	Oncogene	2008
22544321	Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio Goloudina, AR, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON	Cell Cycle	2012