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PTPN12 [nucleoplasm]
Stable Identifier
R-HSA-9008905
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PTP-PEST, Tyrosine-protein phosphatase non-receptor type 12, PTN12_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-37 signaling (Homo sapiens)
PTPNs gene transcription and translation (Homo sapiens)
PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
PTPN12 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05209 PTPN12
Gene Names
PTPN12
Chain
chain:1-780
Reference Genes
BioGPS Gene:5782 PTPN12
COSMIC (genes):PTPN12 PTPN12
CTD Gene:5782 PTPN12
dbSNP Gene:5782 PTPN12
ENSEMBL:ENSG00000127947 PTPN12
ENSEMBL_homo_sapiens_GENE:ENSG00000127947.16 PTPN12
HGNC:9645 PTPN12
KEGG Gene (Homo sapiens):5782 PTPN12
Monarch:5782 PTPN12
NCBI Gene:5782 PTPN12
OMIM:600079 PTPN12
UCSC:Q05209 PTPN12
Reference Transcript
RefSeq:NM_001131009.1 PTPN12
RefSeq:NM_002835.3 PTPN12
RefSeq:NM_001131008.1 PTPN12
Other Identifiers
11717887_s_at
11732037_a_at
11740181_a_at
1463_at
17047652
202006_PM_at
202006_at
216915_PM_s_at
216915_s_at
3009960
3009961
3009962
3009963
3009964
3009976
3009977
3009979
3009981
3009982
3009983
3009985
3009993
3009995
3009996
3009997
3009999
3010004
3010007
3010010
3010012
3010014
3010015
3010016
5782
8133788
A_14_P126061
A_23_P8763
GE58151
GO:0002102
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005925
GO:0006470
GO:0016311
GO:0016787
GO:0016791
GO:0017124
GO:0023052
GO:0035335
GO:0036211
GO:0042058
GO:0042246
GO:0042995
GO:0043226
GO:0043229
GO:0048856
GO:0070161
GO:0071364
GO:0140096
GO:1901185
GO:2000587
HMNXSV003039324
Hs.62.1.S1_3p_a_at
ILMN_1695509
ILMN_2222074
M93425_at
PH_hs_0000009
TC07000495.hg
TC07002426.hg
g4506286_3p_at
Participates
as a member of
PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PTPN12 [cytosol]
Cross References
RefSeq
NP_001124480.1
,
NP_001124481.1
,
NP_002826.3
OpenTargets
ENSG00000127947
HPA
ENSG00000127947-PTPN12
GeneCards
Q05209
ZINC - Substances
PTN12_HUMAN
ZINC target
Q05209
Ensembl
ENSG00000127947
,
ENST00000415482
,
ENST00000435495
,
ENST00000248594
,
ENSP00000248594
,
ENSP00000392429
,
ENSP00000397991
PRO
Q05209
Pharos - Targets
Q05209
ZINC - Predictions - Purchasable
PTN12_HUMAN
PDB
5HDE
,
5J8R
,
5O2P
HMDB Protein
HMDBP08927
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.856
9
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.835
9
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.807
5
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.762
4
UniProt:Q9H939 PPIP2
0.745
6
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.704
3
UniProt:P56945 BCAR1
4
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
BCAR1 [cytosol]
(R-HSA-201625)
0.691
5
UniProt:P42768 WAS
2
WAS [cytosol]
(R-HSA-201879)
p-Y291-WAS [cytosol]
(R-HSA-2197668)
0.609
2
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.592
4
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.564
3
UniProt:Q9P0L0 VAPA
4
VAPA [endoplasmic reticulum membrane]
(R-HSA-429677)
VAPA [azurophil granule membrane]
(R-HSA-6799364)
VAPA [plasma membrane]
(R-HSA-6806269)
VAPA [cytosol]
(R-HSA-9609920)
0.527
3
UniProt:O60711 LPXN
0.527
3
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