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p-S280,S298-RUNX2-P2 [nucleoplasm]
Stable Identifier
R-HSA-9009192
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S280,S298-RUNX2-proximal
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RUNX2 regulates osteoblast differentiation (Homo sapiens)
Activated ERKs phosphorylate RUNX2 (Homo sapiens)
p-2S-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-2S-RUNX2 [nucleoplasm] (Homo sapiens)
p-S280,S298-RUNX2-P2 [nucleoplasm] (Homo sapiens)
BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-2S-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-2S-RUNX2 [nucleoplasm] (Homo sapiens)
p-S280,S298-RUNX2-P2 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB):BGLAP gene [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-2S-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-2S-RUNX2 [nucleoplasm] (Homo sapiens)
p-S280,S298-RUNX2-P2 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB binds BGLAP gene promoter (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-2S-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-2S-RUNX2 [nucleoplasm] (Homo sapiens)
p-S280,S298-RUNX2-P2 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB):BGLAP gene [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-2S-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-2S-RUNX2 [nucleoplasm] (Homo sapiens)
p-S280,S298-RUNX2-P2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13950-2 RUNX2
Gene Names
RUNX2, AML3, CBFA1, OSF2, PEBP2A
Participates
as a candidate of
p-2S-RUNX2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RUNX2-P2 [nucleoplasm]
RUNX2-P2 [cytosol]
p-S451-RUNX2-P2 [nucleoplasm]
p-S418-RUNX2-P2 [nucleoplasm]
PolyUb-RUNX2-P2 [cytosol]
PolyUb-RUNX2-P2 [nucleoplasm]
p-S280,S284,S288-RUNX2-P2 [nucleoplasm]
p-S182,T184,T186-RUNX2-P2 [nucleoplasm]
Inferred To
phospho-RunxB [nucleoplasm]
(Drosophila melanogaster)
Homologues of p-S280,S298-RUNX2-P2 [nucleoplasm]
(Drosophila melanogaster)
phospho-run [nucleoplasm]
(Drosophila melanogaster)
phospho-Runx2 [nucleoplasm]
(Mus musculus)
phospho-p-S280,S298-RUNX2-P2 [nucleoplasm]
(Bos taurus)
phospho-p-S280,S298-RUNX2-P2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S280,S298-RUNX2-P2 [nucleoplasm]
(Gallus gallus)
phospho-lz [nucleoplasm]
(Drosophila melanogaster)
phospho-RUNX2 [nucleoplasm]
(Canis familiaris)
phospho-RUNX2 [nucleoplasm]
(Sus scrofa)
phospho-RunxA [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-serine at 280
Coordinate
280
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 298
Coordinate
298
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
OpenTargets
ENSG00000124813
ENSEMBL
ENST00000359524
,
ENST00000371438
,
ENST00000371436
,
ENSP00000360493
,
ENSP00000360491
,
ENSP00000495497
,
ENST00000371432
,
ENSG00000124813
,
ENST00000647337
,
ENSP00000360486
,
ENSP00000352514
HPA
ENSG00000124813-RUNX2
GeneCards
RUNX2
PRO
Q13950
Pharos - Targets
Q13950
Orphanet
RUNX2
GlyGen
Q13950
PDB
6VGE
,
6VG8
,
6VGD
,
6VGG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.602
4
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.591
7
UniProt:P17480 UBTF
2
UBTF [nucleoplasm]
(R-HSA-73683)
p-UBTF [nucleoplasm]
(R-HSA-76039)
0.564
4
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.527
3
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