Reactome | Proteasome degrades PolyUb-RUNX2

Proteasome degrades PolyUb-RUNX2

Stable Identifier

R-HSA-9009362

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RUNX2 polyubiquitinated by STUB1 (CHIP) (Li et al. 2008) or SMURF1 (Zhao et al. 2003, Yang et al. 2014) is degraded by the proteasome.

Literature References

PubMed ID	Title	Journal	Year
18541707	CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation Ren, F, Shi, Y, Zhai, Y, Irwin, DM, Li, X, Chang, Z, Shang, Y, Zheng, H, Huang, M, Chen, D, Wang, Y	J. Cell Biol.	2008
25260729	A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells Guan, L, Yang, F, Lu, Q, Zhang, Y, Li, D, Zhang, X, Xu, N, He, Y	J Endod	2014
12738770	E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation Oyajobi, BO, Qiao, M, Zhao, M, Mundy, GR, Chen, D	J. Biol. Chem.	2003