Binding of AP1 transcriptional activator complexes to CCND1 promoter

Stable Identifier
R-HSA-9009371
Type
Reaction [binding]
Species
Homo sapiens
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Although there is not a classical estrogen response element (ERE) in the proximal CCND1 promoter, estrogen-responsive transcription is mediated through recruitment of hormone-bound ESR1 by other DNA-binding proteins (reviewed in Guo et al, 2011; Klein and Assoian, 2008). A heterodimer of JUN:FOS binds to an estrogen-responsive G1 element (ERGE) between nucleotides -948 and -925 and is responsible for recruitment of ESR1 and estrogen to this site. OCT1 may facilitate this binding by displacing a YY1:HDAC1 repressive complex that occupies an adjacent site in unstimulated cells (Albanese et al, 1995; Cicatiello et al, 2004; Shen et al, 2007). Binding of ATF2:JUN heterodimers to a cyclic AMP response element (CRE) located 52 nucleotides upstream of the transcriptional start site may also contribute to estrogen-responsive signaling (Sabbah et al, 1999; Castro-Rivera at al, 2001). An ERE has been identified in an enhancer element downstream of the CCND1 gene (enh2). This enhancer binds to FOXA1, and also mediates recruitment of the histone acetyltransferase p300 to the CCND1 promoter (Eeckhoute et al, 2006).
Although FOXA1 and GATA3 were initially characterized as 'pioneer' transcription factors that bind to closed chromatin conformations and prime recruitment of sequence-specific DNA binding factors, more recent studies have questioned the order of recruitment of the estrogen receptors, FOXA1 and GATA3 to estrogen-responsive targets (Swinstead et al, 2016).

Literature References
PubMed ID Title Journal Year
22704330 The elements of human cyclin D1 promoter and regulation involved

Guo, ZY, Hao, XH, Tan, FF, Pei, X, Shang, LM, Jiang, XL, Yang, F

Clin Epigenetics 2011
27062924 Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

Swinstead, EE, Miranda, TB, Paakinaho, V, Baek, S, Goldstein, I, Hawkins, M, Karpova, TS, Ball, D, Mazza, D, Lavis, LD, Grimm, JB, Morisaki, T, Grøntved, L, Presman, DM, Hager, GL

Cell 2016
16980581 A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer

Eeckhoute, J, Carroll, JS, Geistlinger, TR, Torres-Arzayus, MI, Brown, M

Genes Dev. 2006
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
17637753 The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors

Shen, Q, Uray, IP, Li, Y, Krisko, TI, Strecker, TE, Kim, HT, Brown, PH

Oncogene 2008
15282324 Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter

Cicatiello, L, Addeo, R, Sasso, A, Altucci, L, Petrizzi, VB, Borgo, R, Cancemi, M, Caporali, S, Caristi, S, Scafoglio, C, Teti, D, Bresciani, F, Perillo, B, Weisz, A

Mol. Cell. Biol. 2004
7559524 Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

Albanese, C, Johnson, J, Watanabe, G, Eklund, N, Vu, D, Arnold, A, Pestell, RG

J. Biol. Chem. 1995
11410592 Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements

Castro-Rivera, E, Samudio, I, Safe, S

J. Biol. Chem. 2001
10500157 Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element

Sabbah, M, Courilleau, D, Mester, J, Redeuilh, G

Proc. Natl. Acad. Sci. U.S.A. 1999
19020303 Transcriptional regulation of the cyclin D1 gene at a glance

Klein, EA, Assoian, RK

J. Cell. Sci. 2008
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