Estrogen-responsive CCND1 gene expression

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R-HSA-9009378
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Reaction [omitted]
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Homo sapiens
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The proliferative effects of estrogen stimulation arise in part through the estrogen-dependent activation of key cell cycle regulators such as Cyclin D1, encoded by the CCND1 gene. Although there is not a classical estrogen response element (ERE) in the proximal CCND1 promoter, estrogen-responsive transcription is mediated through recruitment of hormone-bound ESR1 by other DNA-binding proteins (reviewed in Guo et al, 2011; Klein and Assoian, 2008). A heterodimer of JUN:FOS binds to an estrogen-responsive G1 element (ERGE) between nucleotides -948 and -925 and is responsible for recruitment of ESR1 and estrogen to this site. OCT1 may facilitate this binding by diplacing a YY1:HDAC1 repressive complex that occupies an adjacent site in unstimulated cells (Albanese et al, 1995; Cicatiello et al, 2004; Shen et al, 2007). Binding of ATF2:JUN heterodimers to a cyclic AMP response element (CRE) located 52 nucleotides upstream of the transcriptional start site may also contribute to estrogen-responsive signaling (Sabbah et al, 1999; Castro-Rivera at al, 2001).

Literature References
PubMed ID Title Journal Year
17637753 The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors

Shen, Q, Uray, IP, Li, Y, Krisko, TI, Strecker, TE, Kim, HT, Brown, PH

Oncogene 2008
22704330 The elements of human cyclin D1 promoter and regulation involved

Guo, ZY, Hao, XH, Tan, FF, Pei, X, Shang, LM, Jiang, XL, Yang, F

Clin Epigenetics 2011
15282324 Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter

Cicatiello, L, Addeo, R, Sasso, A, Altucci, L, Petrizzi, VB, Borgo, R, Cancemi, M, Caporali, S, Caristi, S, Scafoglio, C, Teti, D, Bresciani, F, Perillo, B, Weisz, A

Mol. Cell. Biol. 2004
7559524 Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

Albanese, C, Johnson, J, Watanabe, G, Eklund, N, Vu, D, Arnold, A, Pestell, RG

J. Biol. Chem. 1995
11410592 Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements

Castro-Rivera, E, Samudio, I, Safe, S

J. Biol. Chem. 2001
10500157 Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element

Sabbah, M, Courilleau, D, Mester, J, Redeuilh, G

Proc. Natl. Acad. Sci. U.S.A. 1999
19020303 Transcriptional regulation of the cyclin D1 gene at a glance

Klein, EA, Assoian, RK

J. Cell. Sci. 2008
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