SMURF1 polyubiquitinates RUNX2

Stable Identifier
R-HSA-9009403
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SMURF1 polyubiquitinates RUNX2
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Based on studies in mice, SMURF1 polyubiquitinates RUNX2, targeting it for degradation (Zhao et al. 2003). In human cells, RUNX2 ubiquitination is decreased upon SMURF1 knockdown (Yang et al. 2014).
Literature References
PubMed ID Title Journal Year
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Guan, L, Yang, F, Lu, Q, Zhang, Y, Li, D, Zhang, X, Xu, N, He, Y

J Endod 2014
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Oyajobi, BO, Qiao, M, Zhao, M, Mundy, GR, Chen, D

J. Biol. Chem. 2003
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Catalyst Activity

ubiquitin protein ligase activity of RUNX2:SMURF1 [cytosol]

Physical Entity
RUNX2:SMURF1 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Inferred From
Smurf1 polyubiquitinates Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-17)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-17)
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