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CSF1 [extracellular region]
Stable Identifier
R-HSA-9009484
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Macrophage colony-stimulating factor 1, CSF1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MARK3 phosphorylates MITF-M on S173 (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1 dimer binds CSF1R or IL34 (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1R dimerizes (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1R trans-autophosphorylates on tyrosine-561 (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Other interleukin signaling (Homo sapiens)
IL34 binds CSF1 (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
IL34:CSF1 [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
IL34:CSF1 binds CSF1R (Homo sapiens)
IL34:CSF1 [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
IL34:CSF1:CSF1R [plasma membrane] (Homo sapiens)
IL34:CSF1 [extracellular region] (Homo sapiens)
CSF1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09603 CSF1
Gene Names
CSF1
Chain
signal peptide:1-32, chain:33-554, chain:33-450, chain:33-255
Reference Genes
BioGPS Gene:1435 CSF1
COSMIC (genes):CSF1 CSF1
CTD Gene:1435 CSF1
dbSNP Gene:1435 CSF1
ENSEMBL:ENSG00000184371 CSF1
HGNC:2432 CSF1
KEGG:hsa:1435 CSF1
Monarch:1435 CSF1
NCBI Gene:1435 CSF1
OMIM:120420 CSF1
UCSC:P09603 CSF1
Reference Transcript
RefSeq:NM_172210.2 CSF1
RefSeq:NM_172212.2 CSF1
RefSeq:NM_000757.5 CSF1
RefSeq:NM_172211.3 CSF1
Other Identifiers
1170_at
11737201_at
11738854_a_at
11739628_a_at
1435
16668420
207082_PM_at
207082_at
209716_PM_at
209716_at
210557_PM_x_at
210557_x_at
211839_PM_s_at
211839_s_at
2351079
2351080
2351081
2351082
2351084
2351085
2351088
2351089
2351092
2351093
2351094
2351095
2351096
2351097
2351098
2351099
2351100
2351104
2351106
2351107
2351108
7903786
882_at
A_14_P103968
A_23_P407012
A_33_P3354935
A_33_P3354940
A_33_P3354945
GE80951
GO:0001780
GO:0001954
GO:0002158
GO:0002376
GO:0002687
GO:0002931
GO:0003006
GO:0005125
GO:0005157
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005886
GO:0006954
GO:0007165
GO:0007169
GO:0007265
GO:0008083
GO:0008284
GO:0010628
GO:0010743
GO:0010744
GO:0010759
GO:0016020
GO:0016604
GO:0022414
GO:0030154
GO:0030224
GO:0030225
GO:0030278
GO:0030316
GO:0030335
GO:0032946
GO:0035702
GO:0038145
GO:0040018
GO:0042117
GO:0042488
GO:0042802
GO:0042803
GO:0045087
GO:0045651
GO:0045657
GO:0045672
GO:0045860
GO:0046579
GO:0048018
GO:0048471
GO:0048856
GO:0048870
GO:0048873
GO:0051247
GO:0060444
GO:0060611
GO:0060763
GO:0061518
GO:0061519
GO:0097529
GO:0098542
GO:0098772
GO:1902228
GO:1904141
GO:1905523
GO:1990682
HMNXSV003019641
HMNXSV003035550
HMNXSV003056374
ILMN_1733402
ILMN_1805930
ILMN_2302947
M37435_at
PH_hs_0010421
TC01000955.hg
g181134_3p_x_at
g4503074_3p_at
g758780_3p_a_at
Participates
as a component of
CSF1 dimer [extracellular region] (Homo sapiens)
IL34:CSF1 [extracellular region] (Homo sapiens)
as an input of
IL34 binds CSF1 (Homo sapiens)
Other forms of this molecule
CSF1 [endoplasmic reticulum lumen]
p-CSF1 [endoplasmic reticulum lumen]
CSF1 [plasma membrane]
Inferred To
Csf1 [extracellular region]
(Mus musculus)
Csf1 [extracellular region]
(Rattus norvegicus)
csf1b [extracellular region]
(Danio rerio)
CSF1 [extracellular region]
(Bos taurus)
CSF1 [extracellular region]
(Canis familiaris)
CSF1 [extracellular region]
(Gallus gallus)
CSF1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_757351.1
,
NP_757350.1
,
NP_000748.3
,
NP_757349.1
OpenTargets
ENSG00000184371
ENSEMBL
ENSP00000407317
,
ENST00000369802
,
ENST00000369801
,
ENST00000420111
,
ENSP00000358817
,
ENSP00000327513
,
ENSP00000358816
,
ENST00000329608
HPA
ENSG00000184371-CSF1
PRO
P09603
Pharos - Targets
P09603
GlyGen
P09603
PDB
4WRM
,
5LXF
,
3UF2
,
4WRL
,
3UEZ
,
1HMC
,
4ADF
,
4FA8
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07333 CSF1R
4
CSF1R [plasma membrane]
(R-HSA-197667)
p-Y561-CSF1R [plasma membrane]
(R-HSA-9733328)
PolyUb,p-Y561-CSF1R [plasma membrane]
(R-HSA-9733335)
PolyUb,p-8Y-CSF1R [plasma membrane]
(R-HSA-389142)
0.884
13
UniProt:P09603 CSF1
4
CSF1 [endoplasmic reticulum lumen]
(R-HSA-8956778)
p-CSF1 [endoplasmic reticulum lumen]
(R-HSA-8956881)
CSF1 [extracellular region]
(R-HSA-9009484)
CSF1 [plasma membrane]
(R-HSA-389148)
0.781
8
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.718
6
UniProt:P03228 BARF1
0.713
9
UniProt:P09581 Csf1r
5
p-Y559-Csf1r [plasma membrane]
(R-MMU-9763882)
PolyUb,p-8Y-Csf1r [plasma membrane]
(R-MMU-9680640)
K48polyUb,p-Y559-Csf1r [plasma membrane]
(R-MMU-9763897)
Csf1r [plasma membrane]
(R-MMU-9680626)
CSF1R [plasma membrane]
(R-MMU-197667)
0.623
2
UniProt:P0CW72 BARF1
0.618
3
UniProt:Q13643 FHL3
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
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