IL34 dimer:SDC1 binds CSF1R

Stable Identifier
R-HSA-9009554
Type
Reaction [uncertain]
Species
Homo sapiens
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Interleukin-34 (IL34) can bind Syndecan-1 (SDC1), a cell surface proteoglycan. Low levels of SDC1 may sequester IL34 at the cell surface and prevent it from binding Macrophage colony-stimulating factor 1 receptor (CSF1R), while high SDC1 levels may facilitate IL34-CSF1R signaling (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. The precise interaction between IL34:SDC1 and CSF1R is unknown. Hence, this interaction is represented as an uncertain black box event.

Literature References
PubMed ID Title Journal Year
25662098 Syndecan-1 regulates the biological activities of interleukin-34

S├ęgaliny, AI, Brion, R, Mortier, E, Maillasson, M, Cherel, M, Jacques, Y, Le Goff, B, Heymann, D

Biochim. Biophys. Acta 2015
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