Reactome | FOSB [nucleoplasm]

FOSB [nucleoplasm]

Stable Identifier

R-HSA-9009922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein fosB, FOSB_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) transcription (Homo sapiens)
        
        AP-1 binding to CD274 gene (Homo sapiens)
        
        AP-1 [nucleoplasm] (Homo sapiens)
        
        FOSB:JUND [nucleoplasm] (Homo sapiens)
        
        FOSB [nucleoplasm] (Homo sapiens)
        
        AP-1:CD274 gene [nucleoplasm] (Homo sapiens)
        
        AP-1 [nucleoplasm] (Homo sapiens)
        
        FOSB:JUND [nucleoplasm] (Homo sapiens)
        
        FOSB [nucleoplasm] (Homo sapiens)
        
        CD274 Transcription (Homo sapiens)
        
        AP-1 [nucleoplasm] (Homo sapiens)
        
        FOSB:JUND [nucleoplasm] (Homo sapiens)
        
        FOSB [nucleoplasm] (Homo sapiens)
        
        AP-1:CD274 gene [nucleoplasm] (Homo sapiens)
        
        AP-1 [nucleoplasm] (Homo sapiens)
        
        FOSB:JUND [nucleoplasm] (Homo sapiens)
        
        FOSB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53539 FOSB

Gene Names

FOSB, G0S3

Chain

chain:1-338

Reference Genes

BioGPS Gene:2354 FOSB

COSMIC (genes):FOSB FOSB

CTD Gene:2354 FOSB

dbSNP Gene:2354 FOSB

ENSEMBL:ENSG00000125740 FOSB

HGNC:3797 FOSB

KEGG:hsa:2354 FOSB

Monarch:2354 FOSB

NCBI Gene:2354 FOSB

OMIM:164772 FOSB

UCSC:P53539 FOSB

Reference Transcript

Other Identifiers

11717344_x_at

11717345_a_at

16863287

202768_PM_at

202768_at

2354

36669_at

3836275

3836276

3836277

3836278

3836279

3836280

3836281

3836282

3836283

3836284

3836285

3836286

3836287

3836288

3836289

3836290

3836291

3836292

3836293

8029693

A_14_P103679

A_23_P429998

GE57784

GE84503

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001975

GO:0003677

GO:0003690

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007565

GO:0009410

GO:0009612

GO:0022414

GO:0032570

GO:0032870

GO:0035094

GO:0042220

GO:0043278

GO:0043565

GO:0045471

GO:0045944

GO:0048148

GO:0051412

GO:0051591

GO:0071277

GO:1990837

HMNXSV003013193

ILMN_1751607

L49169_at

PH_hs_0004361

TC19000647.hg

TC19002172.hg

g5803016_3p_at

Participates

as a member of

FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)

as a component of

FOSB:JUND [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001107643.1, NP_001397998.1, XP_005258748.1, NP_006723.2

OpenTargets

ENSG00000125740

ENSEMBL

ENSG00000125740, ENSP00000407207, ENST00000417353, ENSP00000414177, ENST00000585836, ENST00000586615, ENSP00000466530, ENSP00000467497, ENST00000592436, ENST00000443841, ENST00000353609, ENSP00000245919, ENSP00000465552, ENSP00000468207, ENST00000591858

HPA

ENSG00000125740-FOSB

GeneCards

FOSB

PRO

P53539

Pharos - Targets

P53539

GlyGen

P53539

PDB

7UCD, 5VPA, 5VPB, 5VPC, 5VPD, 7UCC, 5VPE, 6UCM, 5VPF, 6UCL, 6UCI

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.742	8
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.69	7
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.666	5
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	6
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.556	3
UniProt:Q01974 ROR2	2	ROR2 [plasma membrane] (R-HSA-197731) ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729)	0.556	3