SLIT1 binds COL4A5

Stable Identifier
R-HSA-9010396
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on studies in zebrafish, SLIT1 binds to a type IV collagen COL4A5, which forms the basement membrane on the surface of the optical tectum. COL4A5 and HSPGs may act synergistically to anchor SLIT1 in the basement membrane. ROBO2 receptor is required for lamina-specific axon pathfinding of retinal ganglion cells in the optical tectum (Xiao et al. 2011).

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