Calnexin/calreticulin cycle

Stable Identifier
R-HSA-901042
Type
Pathway
Species
Homo sapiens
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The unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and Parodi AJ, 2008), but in certain cases can occur even in the absence of glycosylation (Ireland BS et al, 2008).

Literature References
PubMed ID Title Journal Year
18303019 Getting in and out from calnexin/calreticulin cycles

Caramelo, JJ, Parodi, AJ

J Biol Chem 2008
18337472 Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules

Ireland, BS, Brockmeier, U, Howe, CM, Elliott, T, Williams, DB

Mol Biol Cell 2008
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