Reactome | LHX4 [nucleoplasm]

LHX4 [nucleoplasm]

Stable Identifier

R-HSA-9010585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

LIM/homeobox protein Lhx4, LHX4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q969G2 LHX4

Gene Names

LHX4

Chain

chain:1-390

Reference Genes

BioGPS Gene:89884 LHX4

COSMIC (genes):LHX4 LHX4

CTD Gene:89884 LHX4

dbSNP Gene:89884 LHX4

ENSEMBL:ENSG00000121454 LHX4

HGNC:21734 LHX4

KEGG:hsa:89884 LHX4

Monarch:89884 LHX4

NCBI Gene:89884 LHX4

OMIM:602146 LHX4

UCSC:Q969G2 LHX4

Reference Transcript

RefSeq:NM_033343.3 LHX4

Other Identifiers

11740405_at

11740406_at

1553156_PM_at

1553156_at

1553157_PM_at

1553157_at

16674540

232781_PM_at

232781_at

2370033

2370034

2370035

2370037

2370038

2370054

2370055

2370057

2370058

2370060

2370061

2370062

2370063

2370065

2370067

57414_at

7907849

89884

A_14_P116231

A_14_P116523

A_23_P23869

A_32_P310219

GO:0000785

GO:0000977

GO:0000981

GO:0001228

GO:0001890

GO:0003677

GO:0005515

GO:0005634

GO:0006355

GO:0006357

GO:0006915

GO:0008045

GO:0008270

GO:0008327

GO:0009887

GO:0012501

GO:0021526

GO:0030154

GO:0030182

GO:0043066

GO:0043226

GO:0043565

GO:0045944

GO:0046872

GO:0048856

GO:0140110

GO:1990837

HMNXSV003007241

Hs.120127.0.S1_3p_at

Hs2.152082.1.S1_3p_at

Hs2.152082.1.S2_3p_at

ILMN_1674366

PH_hs_0006630

PH_hs_0023260

TC01001561.hg

Participates

as a component of

ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSG00000121454, ENST00000263726, ENSP00000263726

OpenTargets

ENSG00000121454

GeneCards

LHX4

HPA

ENSG00000121454-LHX4

PRO

Q969G2

Pharos - Targets

Q969G2

Orphanet

LHX4

PDB

5HOD

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5N6 ORC6	4	ORC6 [nucleoplasm] (R-HSA-68539) ORC6 [cytosol] (R-HSA-9734663) p-T195-ORC6 [cytosol] (R-HSA-9734682) p-T195-ORC6 [nucleoplasm] (R-HSA-9734715)	0.781	8
UniProt:P61371 ISL1	1	ISL1 [nucleoplasm] (R-HSA-400478)	0.745	4
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.666	4
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.659	4
UniProt:P36404 ARL2	2	ARL2 [mitochondrial matrix] (R-HSA-5250216) ARL2 [cytosol] (R-HSA-5216230)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.527	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.527	2
UniProt:Q68CP9 ARID2	1	ARID2 [nucleoplasm] (R-HSA-5225613)	0.483	2
UniProt:O00712 NFIB	1	NFIB [nucleoplasm] (R-HSA-60136)	0.471	2
UniProt:Q12857 NFIA	1	NFIA [nucleoplasm] (R-HSA-60134)	0.471	2

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