Reactome: A Curated Pathway Database

SLITs bind keratan sulfate

Stable Identifier
R-HSA-9010815
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SLIT2 is expressed by corneal epithelial cells and able to bind to keratan sulfate, which is part of the corneal stroma extracellular matrix. This interaction may influence corneal nerve growth cone penetration. SLIT3 may also interact with keratan sulfate, as well as ROBO receptors ROBO1 and ROBO2 (Conrad et al. 2010).

Literature References
Participants
Participant Of
Orthologous Events