Proteasome degrades ubiquitinated ROBO3.1

Stable Identifier
R-HSA-9011313
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Proteasome degrades ubiquitinated ROBO3.1
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Based on studies using recombinant C. elegans proteins expressed in human 293T cells, ZSWIM8-mediated ubiquitination of ROBO3.1 targets ROBO3.1 for proteasome-mediated degradation (Wang et al. 2013).
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Output
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Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Inferred From
Proteasome degrades SAX-3 ubiquitinated by EBAX-1 (Caenorhabditis elegans)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-29)
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