Estrogen-responsive KDM4B gene expression

Stable Identifier
R-HSA-9011966
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Estrogen-responsive KDM4B gene expression
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KDM4B regulates its own expression by interacting with the estrogen receptor to promote estrogen-dependent demethylation of its promoter. KDM4B also interacts with the transcriptional activator SMARCA4 to promote recruitment of RNA polymerase II (Kawazu et al, 2011; Gaughan et al, 2013).
Literature References
PubMed ID Title Journal Year
23723241 KDM4B is a master regulator of the estrogen receptor signalling cascade

Wade, M, O'Neill, D, Gaughan, L, Stockley, J, Tse, S, Robson, CN, Moore, M, Coffey, K, Rogerson, L, Jones, DL, Wright, J

Nucleic Acids Res. 2013
21445275 Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development

Okada, H, McQuire, T, Goto, K, Mak, TW, Miyagishi, M, Son, DO, Saso, K, Kawazu, M, Wakeham, A, Tong, KI

PLoS ONE 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
KDM4B gene:nucleoplasm:ESR1:ESTG [nucleoplasm] (Homo sapiens)
Active Unit
ESR1 dimer:ESTG [nucleoplasm]
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-07)
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