EP300 is recruited to MYC and BCL2 genes

Stable Identifier
R-HSA-9011981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ESR1 and HIST1H2AC contribute to estrogen-responsive transcriptional activation at the BCL and MYC genes by promoting long-range chromatin loops between enhancer elements. This is accompanied by the recruitment of EP300 and RNA polymerase II (Su et al, 2014).

Literature References
PubMed ID Title Journal Year
24371278 An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells

Su, CH, Tzeng, TY, Cheng, C, Hsu, MT

Nucleic Acids Res. 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created