KDM1A is recruited to MYC and BCL2 genes

Stable Identifier
R-HSA-9011984
Type
Reaction [binding]
Species
Homo sapiens
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Histone demethylase KDM1A (also known as LSD1) is recruited to estrogen-responsive promoters and enhancers in a manner that depends on the HAR domain of HIST1H2AC. KDM1A removes the repressive H3K9me2 epigenetic mark, and consistent with this, KDM1A knockdown leads to abrogated expression of BCL2 and MYC genes in response to estrogen stimulation (Perillo et al, 2008; Su et al, 2014; Wang et al, 2009; Wissmann et al, 2007)

Literature References
PubMed ID Title Journal Year
17277772 Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

Wissmann, M, Yin, N, Müller, JM, Greschik, H, Fodor, BD, Jenuwein, T, Vogler, C, Schneider, R, Günther, T, Buettner, R, Metzger, E, Schüle, R

Nat. Cell Biol. 2007
18187655 DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression

Perillo, B, Ombra, MN, Bertoni, A, Cuozzo, C, Sacchetti, S, Sasso, A, Chiariotti, L, Malorni, A, Abbondanza, C, Avvedimento, EV

Science 2008
19098913 The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Wang, J, Hevi, S, Kurash, JK, Lei, H, Gay, F, Bajko, J, Su, H, Sun, W, Chang, H, Xu, G, Gaudet, F, Li, E, Chen, T

Nat. Genet. 2009
24371278 An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells

Su, CH, Tzeng, TY, Cheng, C, Hsu, MT

Nucleic Acids Res. 2014
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