KDM1A demethylates H3 on MYC and BCL genes in response to estrogen

Stable Identifier
R-HSA-9011985
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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KDM1A removes the H3K9me2 repressive epigenetic mark at estrogen-responsive enhancers, allowing transcriptional activation (Wang et al, 2009; Su et al, 2014).

Literature References
PubMed ID Title Journal Year
24371278 An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells

Su, CH, Tzeng, TY, Cheng, C, Hsu, MT

Nucleic Acids Res. 2014
19098913 The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Wang, J, Hevi, S, Kurash, JK, Lei, H, Gay, F, Bajko, J, Su, H, Sun, W, Chang, H, Xu, G, Gaudet, F, Li, E, Chen, T

Nat. Genet. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity (H3-K9 specific) of MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created