p-TEFb phosphorylates serine 2 in RNA polymerase II CTD

Stable Identifier
R-HSA-9012319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Transcriptional pausing at the SL-dT site in the MYB gene is overcome in response to estrogen by the P-TEFb-mediated phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II (Drabsch et al, 2007; Mitra et al, 2012).
Literature References
PubMed ID Title Journal Year
17690249 Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells

Barry, SC, Miao, YR, Drabsch, Y, Gonda, TJ, Dowhan, DH, Ramsay, RG, Gewirtz, AM, Hugo, H, Zhang, R

Proc. Natl. Acad. Sci. U.S.A. 2007
22492511 Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

Pereira, LA, Drabsch, Y, Mitra, P, Gonda, TJ, Ramsay, RG

Nucleic Acids Res. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm]

Physical Entity
MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Gallus gallus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Plasmodium falciparum)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-12)
Cite Us!