p-TEFb phosphorylates serine 2 in RNA polymerase II CTD

Stable Identifier
R-HSA-9012319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Transcriptional pausing at the SL-dT site in the MYB gene is overcome in response to estrogen by the P-TEFb-mediated phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II (Drabsch et al, 2007; Mitra et al, 2012).

Literature References
PubMed ID Title Journal Year
22492511 Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

Mitra, P, Pereira, LA, Drabsch, Y, Ramsay, RG, Gonda, TJ

Nucleic Acids Res. 2012
17690249 Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells

Drabsch, Y, Hugo, H, Zhang, R, Dowhan, DH, Miao, YR, Gewirtz, AM, Barry, SC, Ramsay, RG, Gonda, TJ

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created