MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR

Stable Identifier
R-HSA-9012721
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Hydrogen sulfide (H2S) produced endogenously has been established as the third gaseous signaling molecule, a smooth muscle relaxant and a neuroprotectant (Kimura 2011a, 2011b). Three enzyme systems produce H2S in the brain, retina and vascular endothelial cells (Shibuya et al. 2009a, 2009b, Mikami et al. 2011). 3-mercaptopyruvate sulphurtransferase (MPST, aka 3MST) in conjunction with cysteine (aspartate) aminotransferase (CAT, aka GOT2) is decribed here. In the second step, 3-mercaptopyruvate sulfurtransferase (MPST aka 3MST) mediates the transfer of a sulfur atom from 3-methylpryuvate (3MPYR) to hydrogensulfite (HSO3-) to form thiosulfate (S2O3(2-)) and pyruvate (PYR) (Yadav et al. 2013).

Literature References
PubMed ID Title Journal Year
23698001 Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase

Yadav, PK, Yamada, K, Chiku, T, Koutmos, M, Banerjee, R

J. Biol. Chem. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-mercaptopyruvate sulfurtransferase activity of MPST [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
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Created