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Ubiquitination of DLL/JAG ligands upon binding to NOTCH3
Stable Identifier
R-HSA-9013069
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)
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Based on an analogy with NOTCH1 and NOTCH2, and on studies of Drosophila Notch, NOTCH ligands DLL1, DLL4, JAG1 and JAG2 are assumed to undergo ubiquitination and endocytosis after binding to NOTCH3 in trans. Ubiquitination of DLL/JAG ligands in mammals is performed by orthologues of Drosophila Mindbomb, MIB1, possibly MIB2, and possibly orthologues of Drosophila Neuralized, NEURL and NEURL1B.
Participants
Input
DLL/JAG:NOTCH3 [plasma membrane]
(Homo sapiens)
x 3
Ub [cytosol]
(Homo sapiens)
Output
Ub-DLL/JAG:NOTCH3 [plasma membrane]
(Homo sapiens)
Entity On Other Cell
MIB/NEURL [cytosol]
(Homo sapiens)
Ub [cytosol]
(Homo sapiens)
DLL/JAG [plasma membrane]
(Homo sapiens)
Participates
as an event of
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Event Information
Go Biological Process
Notch signaling pathway (0007219)
Catalyst Activity
ubiquitin-protein transferase activity of MIB/NEURL [cytosol]
Physical Entity
MIB/NEURL [cytosol]
(Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Inferred From
DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1) (Drosophila melanogaster)
Authored
Orlic-Milacic, M (2017-09-20)
Reviewed
Haw, R (2017-10-30)
Created
Orlic-Milacic, M (2017-07-22)
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