NEXT3 is cleaved to produce NICD3

Stable Identifier
R-HSA-9013361
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEXT3 fragment of NOTCH3 is further cleaved at the S3 site by the gamma-secretase complex, containing either PSEN1 (presenilin-1) or PSEN2 (presenilin-2) as the catalytic subunit, which releases the intracellular domain NICD3 into the cytosol (Groot et al. 2014).

Literature References
PubMed ID Title Journal Year
24842903 Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins

Groot, AJ, Habets, R, Yahyanejad, S, Hodin, CM, Reiss, K, Saftig, P, Theys, J, Vooijs, M

Mol. Cell. Biol. 2014
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
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