RHOQ GTPase cycle

Stable Identifier
Homo sapiens
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This pathway catalogues RHOQ (also known as TC10) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOQ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOQ. Two GDIs, ARHGDIA (also known as Rho-GDI alpha) (Michaelson et al. 2001; Murphy et al. 2001) and ARHGDIB (also known as D4-GDI) (Zhang et al. 2009), were specifically shown not to interact with RHOQ. RHOQ, together with RHOJ (TCL), belongs to the CDC42 subfamily of RHO GTPases, with the three family members sharing 65-85% of homology (Murphy et al. 1999, Vignal et al. 2000, Donnelly et al. 2014; Shi et al. 2016). RHOQ is highly activated on exocytosing vesicles and recycling endosomes. RHOQ GTPase activity is necessary for fusion of vesicles with the plasma membrane (Kawase et al. 2006, Donnelly et al. 2014). RHOQ is required for insulin-stimulated glucose uptake (Kanzaki and Pessin 2003; Saltiel and Pessin 2003) and is involved in insulin signaling in adipocytes (Satoh 2014). While some studies reported RHOQ involvement in neurite outgrowth (Abe et al. 2003, Gonzalez‐Billault et al. 2012) and regulation of membrane addition during axon formation (Dupraz et al. 2009, Gonzalez‐Billault et al. 2012), other studies failed to identify RHOQ as a regulator of neurite outgrowth (Murphy et al. 1999, Murphy et al. 2001).
Literature References
PubMed ID Title Journal Year
19846717 The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons

Dupraz, S, Gastaldi, L, Jausoro, I, Caceres, A, Bisbal, M, Grassi, D, Quiroga, S, Sosa, L, Bernis, ME, Pfenninger, KH

J Neurosci 2009
19269969 Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling

Rivera Rosado, LA, Zhang, Y, Zhang, B, Moon, SY

J. Biol. Chem. 2009
12867054 Insulin signaling: GLUT4 vesicles exit via the exocyst

Pessin, JE, Kanzaki, M

Curr. Biol. 2003
10967094 Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

Blangy, A, Gauthier-Rouvière, C, Vignal, E, De Toledo, M, Ladopoulou, A, Comunale, F, Fort, P

J. Biol. Chem. 2000
14617354 Insulin signaling in microdomains of the plasma membrane

Pessin, JE, Saltiel, AR

Traffic 2003
27556037 The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology

Xiao, HT, Shi, TT, Li, G

Biomed Res Int 2016
11306516 Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways

Murphy, GA, Michaelson, D, Philips, MR, Rush, MG, D'Eustachio, P, Jillian, SA

Cell Growth Differ. 2001
22605667 The role of small GTPases in neuronal morphogenesis and polarity

Henriquez, DR, Caceres, A, Muñoz-Llancao, P, Wojnacki, J, Conde, C, González-Billault, C

Cytoskeleton (Hoboken) 2012
11149925 Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

Silletti, J, Michaelson, D, Philips, MR, Rush, MG, D'Eustachio, P, Murphy, GA

J. Cell Biol. 2001
24613967 Rho GTPases in insulin-stimulated glucose uptake

Satoh, T

Small GTPases 2014
16950130 GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion

Takemoto, H, Aoki, K, Takaya, A, Matsuda, M, Namikawa, K, Inagaki, S, Nakamura, T, Saltiel, AR, Kiyama, H, Kawase, K

Dev Cell 2006
25482645 Rho GTPase isoforms in cell motility: Don't fret, we have FRET

Bravo-Cordero, JJ, Hodgson, L, Donnelly, SK

Cell Adh Migr 2014
10445846 Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth

Der, CJ, Jillian, SA, Solski, PA, Rush, MG, Perez de la Ossa, P, D'Eustachio, P, Murphy, GA

Oncogene 1999
12456725 Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth

Kato, M, Takenawa, T, Miki, H, Endo, T, Abe, T

J. Cell. Sci. 2003
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