Reactome | RHOT2 GTPase cycle

RHOT2 GTPase cycle

Stable Identifier

R-HSA-9013419

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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General

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This pathway catalogues guanine nucleotide exchange factors (GEFs) and effectors of RHOT2 (also known as MIRO-2). RHOT2 possesses a high intrinsic GTP-ase activity and does not require a GTPase activator protein (GAP) (Peters et al. 2018). No GDP dissociation inhibitors (GDIs) have been reported to interact with RHOT2. RHOT2 is a mitochondrial RHO GTPase. Like related RHOT1 (MIRO-1), RHOT2 localizes to the outer mitochondrial membrane. Similar to RHOT1, RHOT2 regulates mitochondrial movement by coupling mitochondria to kinesin and dynein motors that transport them along microtubules (Devine et al. 2016). RHOT2 is also localized to peroxisomes and it is involved in peroxisomal dynamics (Covill-Cooke et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
31894645	Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2 Covill-Cooke, C, Toncheva, VS, Drew, J, Birsa, N, Lopez-Domenech, G, Kittler, JT	EMBO Rep	2020
30513825	Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism Peters, DT, Kay, L, Eswaran, J, Lakey, JH, Soundararajan, M	Int J Mol Sci	2018
26707701	Miro sculpts mitochondrial dynamics in neuronal health and disease Devine, MJ, Birsa, N, Kittler, JT	Neurobiol. Dis.	2016