HES1 gene expression is stimulated by NOTCH3 and STAT1

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Reaction [omitted]
Homo sapiens
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Based on studies in a mouse system, HES1 gene expression is directly stimulated by the NOTCH3 coactivator complex (Lin et al. 2002, Shimizu et al. 2002). Activated STAT1 directly enhances HES1 transcription induced by NICD3 (Boelens et al. 2014).

Literature References
PubMed ID Title Journal Year
11866432 Functional diversity among Notch1, Notch2, and Notch3 receptors

Shimizu, K, Hirai, H, Kumano, K, Hamada, Y, Saito, T, Chiba, S

Biochem Biophys Res Commun 2002
12386158 Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling

Oyama, T, Nagase, T, Lin, SE, Kitagawa, M, Harigaya, K

J. Biol. Chem. 2002
25417103 Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways

Wiemann, BZ, Qiu, Y, Nabet, BY, Ishwaran, H, Wu, TJ, Slingerland, J, Twyman-Saint Victor, C, Xu, B, Minn, AJ, Yoon, T, Ter Brugge, PJ, Jonkers, J, Boelens, MC, Azzam, DJ

Cell 2014
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