HES1 gene expression is stimulated by NOTCH4

Stable Identifier
R-HSA-9013711
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HES1 gene expression is stimulated by NOTCH4
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NOTCH4 expression correlates with increased HES1 gene transcription in different cell types (Raafat et al. 2004, Lai et al. 2013, Simoes et al. 2015). A recombinant human NICD4 stimulates transcription from the recombinant human HES1-luciferase reporter construct (Raafat et al. 2004).
Literature References
PubMed ID Title Journal Year
15531924 Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh)

Bargo, S, Callahan, R, Raafat, A, Anver, MR

Oncogene 2004
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of transcription, DNA-templated (0045893)
This event is regulated
Positively by
Regulator
NOTCH4 coactivator complex [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2017-07-25)
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