TXLNA (IL14) binds syntaxin3

Stable Identifier
R-HSA-9014052
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Interleukin-14, renamed alpha-taxilin (TXLNA) was originally described as High molecular weight B-cell growth factor (Ambrus et al. 1994). TXLNA binds several forms of syntaxin (Nogami et al. 2003), but not when they are complexed with SNAP25, VAMP2 or STXBP1, suggesting that TXLNA interacts with syntaxins outside the SNARE complex. This observation and a predicted role in intracellular vesicle trafficking led to renaming of the gene. Txlna transgenic mice show a phenotype similar to systemic lupus erythematosus and Sjogren's syndrome (Shen et al. 2006).

Literature References
PubMed ID Title Journal Year
12558796 Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells

Nogami, S, Satoh, S, Nakano, M, Shimizu, H, Fukushima, H, Maruyama, A, Terano, A, Shirataki, H

Genes Cells 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed